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ABT-874, a fully human monoclonal anti-IL-12/IL-23 antibody for the potential treatment of autoimmune diseases.

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Ding, C, Xu, J and Li, J 2008 , 'ABT-874, a fully human monoclonal anti-IL-12/IL-23 antibody for the potential treatment of autoimmune diseases.' , Current Opinion in Investigational Drugs, vol. 9, no. 5 , pp. 515-522 .

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Abstract

ABT-874, a fully human mAb that blocks the binding of IL-12 and IL-23 to their shared IL-12 receptor beta1, is currently being developed by Abbott Laboratories for the potential treatment of Crohn's disease and psoriasis. The compound is currently in phase III clinical trials for psoriasis and phase II trials for Crohn's disease. ABT-87 was previously being developed for the potential treatment of multiple sclerosis; however, by May 2007, development for this indication was discontinued.

Item Type: Article
Authors/Creators:Ding, C and Xu, J and Li, J
Journal or Publication Title: Current Opinion in Investigational Drugs
ISSN: 1472-4472
Additional Information:

Changhai Ding

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