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Validation of linear cerebral atrophy markers in multiple sclerosis


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Butzkueven, H, Kolbe, SC, Jolley, DJ, Brown, JY, Cook, MJ, van der Mei, IAF, Groom, PS, Carey, J, Eckholdt, J, Rubio, JP, Taylor, BV, Mitchell, PJ, Egan, GF and Kilpatrick, TJ 2008 , 'Validation of linear cerebral atrophy markers in multiple sclerosis' , Journal of Clinical Neuroscience, vol. 15, no. 2 , pp. 130-137 , doi: 10.1016/j.jocn.2007.02.089.

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Linear measures of cerebral ventricular enlargement may act as surrogate measures of cerebral atrophy in multiple sclerosis (MS). Linear atrophy markers were measured from routine MRI scans during a population survey of 171 Tasmanian MS patients and 91 healthy controls. Thirty-five Victorian MS clinic patients were recruited as a validation cohort with 14 of these re-assessed 4 years later. In the population survey, we measured three linear brain atrophy markers: inter-caudate distance (ICD), third ventricle width (TVW) and frontal horn width (FHW). TVW (OR 2.0, p=0.001) and ICD (OR 16.1, p<0.001) differentiated between MS cases and controls. In the validation study, we correlated the intercaudate ratio (ICR=ICD/brain width) and third ventricular ratio (TVR=TVW/brain width) with brain parenchymal volume. Cross-sectionally, ICR (R=-0.453, p<0.01) and TVR (R=-0.653, p<0.01) were correlated with brain parenchymal volume. Longitudinally, brain parenchymal volume loss was inversely correlated with increased ICD (R=-0.77, p<0.01) and TVW (R=-0.71, p<0.01). This study shows that ICD measurements obtained from clinical MRI scans are valid brain atrophy measures for use in monitoring MS progression.

Item Type: Article
Authors/Creators:Butzkueven, H and Kolbe, SC and Jolley, DJ and Brown, JY and Cook, MJ and van der Mei, IAF and Groom, PS and Carey, J and Eckholdt, J and Rubio, JP and Taylor, BV and Mitchell, PJ and Egan, GF and Kilpatrick, TJ
Keywords: Multiple sclerosis; Magnetic resonance imaging; Biological markers; Atrophy; Disease progression; Patient monitoring
Journal or Publication Title: Journal of Clinical Neuroscience
DOI / ID Number: 10.1016/j.jocn.2007.02.089
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