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Wound healing response is a major contributor to the severity of cutaneous leishmaniasis in the ear model of infection

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Baldwin, T and Sakthianandeswaren, A and Curtis, JM and Kumar, B and Smyth, GK and Foote, SJ and Handman, E (2007) Wound healing response is a major contributor to the severity of cutaneous leishmaniasis in the ear model of infection. Parasite Immunology, 29 (10). pp. 501-513. ISSN 1365-3024

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Abstract

In the conventional mouse model for cutaneous leishmaniasis
involving infection with stationary phase
Leishmania major
promastigotes at the base of the tail, mice congenic for
leishmaniasis resistance loci designated lmr1,2,3 cured their
lesions more rapidly and laid down more ordered collagen
fibres than the susceptible parental BALB/c mice, while the
opposite was the case for the congenic mice carrying the
susceptibility loci on the resistant C57BL/6 background. In
that model, we showed that wound healing and not T cell
responses played a major role in determining the resolution of
skin infection. Here, we show a similar disease phenotype in
the mouse model that mimics more closely the situation in
humans, that is, strictly intradermal infection in the ear pinna
with small numbers of metacyclic promastigotes. The data
show that at the site of infection the innate and adaptive
immune responses act in concert to clear parasites, and induce
tissue repair and wound healing. Importantly, the data show
that the host responses controlled by the lmr loci, which act
locally to control infection in the skin, are distinct from the host
responses operating systemically in the draining lymph node.

Item Type: Article
Keywords: collagen deposition, Leishmania , resistance to infection, wound healing
Journal or Publication Title: Parasite Immunology
Page Range: pp. 501-513
ISSN: 1365-3024
Identification Number - DOI: 10.1111/j.1365-3024.2007.00969.x
Additional Information:

The definitive version is available at www.blackwell-synergy.com

Date Deposited: 02 Jul 2008 01:37
Last Modified: 18 Nov 2014 03:44
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