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CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population

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Wray, BN, Stankovich, J, Whittock, L, Dwyer, T, Ponsonby, AL, van der Mei, IAF, Taylor, BV, Dickinson, JL, Foote, SJ and McMorran, BJ 2008 , 'CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population' , Journal of Neuroimmunology, vol. 196, no. 1-2 , pp. 139-142 , doi: 10.1016/j.jneuroim.2008.02.001.

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Abstract

Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of
MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P b 0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.

Item Type: Article
Authors/Creators:Wray, BN and Stankovich, J and Whittock, L and Dwyer, T and Ponsonby, AL and van der Mei, IAF and Taylor, BV and Dickinson, JL and Foote, SJ and McMorran, BJ
Keywords: Multiple sclerosis; Cytotoxic T lymphocyte-associated antigen-4; Major histocompatibility complex; Genetic association
Journal or Publication Title: Journal of Neuroimmunology
ISSN: 0165-5728
DOI / ID Number: 10.1016/j.jneuroim.2008.02.001
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