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Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats

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Powell, KL, Ng, C, O'Brien, TJ, Xu, SH, Williams, D, Foote, SJ and Reid, CA 2008 , 'Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats' , Epilepsia, vol. 49, no. 10 , pp. 1686-1695 , doi: 10.1111/j.1528-1167.2008.01593.x.

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Abstract

Studies in animal models and patients have implicated changes in hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) expression in the pathogenesis of temporal lobe epilepsy (TLE). However, the nature of HCN changes during the epileptogenic process and their commonality across different TLE models is unknown. Here HCN1 and HCN2 mRNA expression was quantitatively measured at different time points during epileptogenesis in two distinct animal models of TLE; the kainic acid (KA)-induced status epilepticus (SE) and amygdala kindling models.

Item Type: Article
Authors/Creators:Powell, KL and Ng, C and O'Brien, TJ and Xu, SH and Williams, D and Foote, SJ and Reid, CA
Keywords: Temporal lobe epilepsy • Amygdala kindling • Kainic acid-induced status epilepticus • Hyperpolarization-activated cyclic nucleotide-gated cation channels
Journal or Publication Title: Epilepsia
ISSN: 0013-9580
DOI / ID Number: 10.1111/j.1528-1167.2008.01593.x
Additional Information:

The original publication is available at
http://www.interscience.wiley.com/

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