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Hop mosaic virus: complete nucleotide sequence and relationship to other carlaviruses


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Poke, FS 2008 , 'Hop mosaic virus: complete nucleotide sequence and relationship to other carlaviruses' , Archives of Virology, vol. 153, no. 8 , pp. 1615-1619 , doi: 10.1007/s00705-008-0157-z.

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Hop mosaic virus (HpMV) is an important virus affecting
hop (Humulus lupulus L.). It has been detected in all the
major hop-growing regions of the world, and its negative
impact upon growth, cone yield and levels of brewing acids
has been documented [8]. HpMV belongs to the family
Flexiviridae and the genus Carlavirus [1]. Typically,
carlaviruses are rod-shaped viruses with a positive, singlestrand
RNA genome encapsulated by coat protein. The
organisation of the genome includes six open reading
frames (ORFs), a 50 cap and a 30 poly(A) tail. The structure
and organisation of the genome is conserved among the
carlaviruses [1]. ORF1 encodes the viral replicase and
accounts for more than 70% of the length of the genome
sequence. This ORF is composed of several functional
domains which contribute to viral replication and which
have a conserved amino acid sequence and order [7]. ORFs
2, 3 and 4 make up the triple gene block. These coding
regions overlap and encode three proteins (TGBP 1, 2 and 3)
that are thought to act in concert to enable virus movement
between cells. ORF 5 encodes the coat protein and is
overlapped by ORF 6, which encodes a nucleic acidbinding
protein that has a putative role as a suppressor of
RNA silencing [7]. The complete genome sequence has so
far been reported for 19 carlaviruses (plus the complete
coding sequence for one other) and varies from 8.2 to 9.1
kilobases (kb), excluding the poly(A) tail.

Item Type: Article
Authors/Creators:Poke, FS
Journal or Publication Title: Archives of Virology
ISSN: 0304-8608
DOI / ID Number: 10.1007/s00705-008-0157-z
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