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Abstract

A simplified preconcentration method for a range of ultra-trace level pharmaceuticals in natural waters has been developed. Solid phase extraction was performed on-line using a micro-reversed-phase monolithic silica column, allowing for very rapid trace enrichment from large volume (500 ml) samples with minimal sample handling. Acceptable recoveries of >70% were obtained for the majority of compounds investigated and the monolithic columns could be washed and conditioned on-line with no sample carryover and used reproducibly for up to eight extractions each. The on-line SPE-LC-UV method was coupled to electrospray ionisation ion trap mass spectrometry (ESI-MS) to increase both selectivity and specificity. Detection limits were determined in spiked river and tap water samples and found to lie in the low ng/l region using sample volumes of 500 ml, loaded at a flow rate of 10 ml/min, and therefore, were suitable for ultra trace analysis.

Item Type:	Article
Authors/Creators:	Bones, J and Thomas, K and Nesterenko, PN and Paull, B
Keywords:	Pharmaceuticals; LC-UV-ESI-MS; On-line SPE; Preconcentration; Monolithic reversed-phase silica
Journal or Publication Title:	Talanta
ISSN:	0039-9140
DOI / ID Number:	10.1016/j.talanta.2006.02.026
Additional Information:	The definitive version is available at http://www.sciencedirect.com
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