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Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients

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Rubio, JP, Bahlo, M, Stankovich, J, Burfoot, RK, Johnson, LJ, Butzkueven, H, Lin, L, Taylor, BV, Speed, TP, Kilpatrick, TJ, Mignot, E and Foote, SJ 2007 , 'Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients' , Immunogenetics, vol. 59, no. 4 , pp. 177-186 , doi: 10.1007/s00251-006-0183-5.

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Abstract

Human leucocyte antigen (HLA)-DRB1*15 is
associated with predisposition to multiple sclerosis (MS),
although conjecture surrounds the possible involvement of
an alternate risk locus in the class I region of the HLA
complex. We have shown previously that an alternate MS
risk allele(s) may be encompassed by the telomerically
extended DRB1*15 haplotype, and here, we have attempted
to map the putative variant.

Item Type: Article
Authors/Creators:Rubio, JP and Bahlo, M and Stankovich, J and Burfoot, RK and Johnson, LJ and Butzkueven, H and Lin, L and Taylor, BV and Speed, TP and Kilpatrick, TJ and Mignot, E and Foote, SJ
Journal or Publication Title: Immunogenetics
ISSN: 0093-7711
DOI / ID Number: 10.1007/s00251-006-0183-5
Additional Information:

The original publication is available at www.springerlink.com

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