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The effect of season on cytokine expression in multiple sclerosis and healthy subjects


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Stewart, NJ and Taylor, BV and Ponsonby, AL and Pittas, F and van der Mei, IAF and Woods, GM and Walters, EH (2007) The effect of season on cytokine expression in multiple sclerosis and healthy subjects. Journal of Neuroimmunology, 188 (1-2). pp. 181-186. ISSN 0165-5728

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We measured the levels of IFNγ, TNFα, Il-4 and Il-10 produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from
healthy people, and those with the relapse/remitting form of multiple sclerosis. Blood was taken in summer and winter. Healthy people had a
summer excess of Il-4, Il-10 and TNFα, and a winter excess of IFNγ. Untreated MS cases had a summer excess of Il-10, whereas those treated
with Interferon-beta had lower levels of all cytokines, and displayed no seasonal effect.

Item Type: Article
Journal or Publication Title: Journal of Neuroimmunology
Page Range: pp. 181-186
ISSN: 0165-5728
Identification Number - DOI: 10.1016/j.jneuroim.2007.06.012
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Date Deposited: 29 Jul 2008 01:47
Last Modified: 18 Nov 2014 03:47
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