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The effect of season on cytokine expression in multiple sclerosis and healthy subjects
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Stewart, NJ, Taylor, BV, Ponsonby, AL, Pittas, F, van der Mei, IAF, Woods, GM and Walters, EH 2007
, 'The effect of season on cytokine expression in multiple sclerosis and healthy subjects'
, Journal of Neuroimmunology, vol. 188, no. 1-2
, pp. 181-186
, doi: 10.1016/j.jneuroim.2007.06.012.
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Official URL: htpp://dx.doi.org/10.1016/j.jneuroim.2007.06.012
Abstract
We measured the levels of IFNγ, TNFα, Il-4 and Il-10 produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from healthy people, and those with the relapse/remitting form of multiple sclerosis. Blood was taken in summer and winter. Healthy people had a summer excess of Il-4, Il-10 and TNFα, and a winter excess of IFNγ. Untreated MS cases had a summer excess of Il-10, whereas those treated with Interferon-beta had lower levels of all cytokines, and displayed no seasonal effect.
| Item Type: | Article |
|---|---|
| Authors/Creators: | Stewart, NJ and Taylor, BV and Ponsonby, AL and Pittas, F and van der Mei, IAF and Woods, GM and Walters, EH |
| Journal or Publication Title: | Journal of Neuroimmunology |
| ISSN: | 0165-5728 |
| DOI / ID Number: | 10.1016/j.jneuroim.2007.06.012 |
| Additional Information: | The definitive version is available at http://www.sciencedirect.com |
| Item Statistics: | View statistics for this item |
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