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New insight into the molecular pathways of metallothionein-mediated neuroprotection and regeneration


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Chung, RS and Hidalgo, J and West, AK (2008) New insight into the molecular pathways of metallothionein-mediated neuroprotection and regeneration. Journal of Neurochemistry, 104 (1). pp. 14-20. ISSN 0022-3042

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There is a large body of evidence demonstrating that metallothioneins (MTs) expressed in astrocytes following CNS
injury, exhibit both neuroprotective and neuroregenerative
properties and are critical for recovery outcomes. As these
proteins lack signal peptides, and have well characterized free radical scavenging and heavy metal binding properties, the neuroprotective functions of MTs have been attributed to
these intracellular roles. However, there is an increasing
realization that the neuroprotective functions of MTs may also involve an extracellular component. In this issue of Journal of Neurochemistry, Ambjørn et al. reveal considerable insight into this novel function of MTs. In this review, we examine the seminal work of Ambjørn et al. in the context of our current understanding of the role of MT in astrocyte-neuron interactions in the injured brain, and also discuss the significant therapeutic potential of their work.

Item Type: Article
Journal or Publication Title: Journal of Neurochemistry
Page Range: pp. 14-20
ISSN: 0022-3042
Identification Number - DOI: 10.1111/j.1471-4159.2007.05026.x
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Date Deposited: 31 Jul 2008 05:51
Last Modified: 18 Nov 2014 03:47
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