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Nonpharmacological and pharmacological interventions to prevent or reduce airway remodelling


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Walters, EH, Reid, DW, Johns, DP and Ward, C 2007 , 'Nonpharmacological and pharmacological interventions to prevent or reduce airway remodelling' , The European Respiratory Journal, vol. 30, no. 3 , pp. 574-588 , doi: 10.1183/09031936.00007306.

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In the present review of airway remodelling and its response to therapies, clinical
observations about airway physiological abnormalities, assumed to be caused by remodelling
processes, are related to what is known about the components of structural changes from airway
sampling and histopathological analysis. The review focuses on three important diseases:
asthma, chronic obstructive pulmonary disease and bronchiolitis obliterans syndrome (BOS),
which occurs commonly after lung transplantation as a manifestation of chronic rejection. The
present authors chose to use BOS as an issue, because with routine bronchoscopic surveillance
after lung transplantation there has been more opportunity to directly study airway pathology
longitudinally than in more everyday conditions. In addition, the present authors have reviewed
animal models of induced airway remodelling, where most information is available on the
potential of therapeutic intervention. Finally, the limited information that can be gained from the
literature on the effects of commonly used airway medications on remodelling components is
reviewed. In conclusion, the present authors have detailed some of the gaps in knowledge
surrounding the potential to improve or modulate remodelling processes in human disease. The
areas where it is believed urgent research needs to be focused have also been highlighted.

Item Type: Article
Authors/Creators:Walters, EH and Reid, DW and Johns, DP and Ward, C
Journal or Publication Title: The European Respiratory Journal
ISSN: 0903-1936
DOI / ID Number: 10.1183/09031936.00007306
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Copyright ©ERS Journals Ltd 2007

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