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Abstract

A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity.

Item Type:	Article
Authors/Creators:	Staroverov, SM and Kuznetsov, MA and Nesterenko, PN and Vasiyarov, GG and Katruha, GS and Fedorova, GB
Keywords:	A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity.
Journal or Publication Title:	Journal of Chromatography A
ISSN:	0021-9673
DOI / ID Number:	10.1016/j.chroma.2006.01.073
Additional Information:	The definitive version is available at http://www.sciencedirect.com
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