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New chiral stationary phase with macrocyclic glycopeptide antibiotic eremomycin chemically bonded to silica
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Staroverov, SM, Kuznetsov, MA, Nesterenko, PN, Vasiyarov, GG, Katruha, GS and Fedorova, GB 2006
, 'New chiral stationary phase with macrocyclic glycopeptide antibiotic eremomycin chemically bonded to silica'
, Journal of Chromatography A, vol. 1108, no. 2
, pp. 263-267
, doi: 10.1016/j.chroma.2006.01.073.
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Official URL: http://dx.doi.org/10.1016/j.chroma.2006.01.073
Abstract
A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity.
Item Type: | Article |
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Authors/Creators: | Staroverov, SM and Kuznetsov, MA and Nesterenko, PN and Vasiyarov, GG and Katruha, GS and Fedorova, GB |
Keywords: | A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity. |
Journal or Publication Title: | Journal of Chromatography A |
ISSN: | 0021-9673 |
DOI / ID Number: | 10.1016/j.chroma.2006.01.073 |
Additional Information: | The definitive version is available at http://www.sciencedirect.com |
Item Statistics: | View statistics for this item |
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