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New chiral stationary phase with macrocyclic glycopeptide antibiotic eremomycin chemically bonded to silica

Staroverov, SM, Kuznetsov, MA, Nesterenko, PN, Vasiyarov, GG, Katruha, GS and Fedorova, GB 2006 , 'New chiral stationary phase with macrocyclic glycopeptide antibiotic eremomycin chemically bonded to silica' , Journal of Chromatography A, vol. 1108, no. 2 , pp. 263-267 , doi: https://doi.org/10.1016/j.chroma.2006.01.073.

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Abstract

A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity.

Item Type: Article
Authors/Creators:Staroverov, SM and Kuznetsov, MA and Nesterenko, PN and Vasiyarov, GG and Katruha, GS and Fedorova, GB
Keywords: A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity.
Journal or Publication Title: Journal of Chromatography A
ISSN: 0021-9673
DOI / ID Number: https://doi.org/10.1016/j.chroma.2006.01.073
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