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Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian Older Adult Cohort (TASOAC) study

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Ding, C and Parameswaran, V and Cicuttini, F and Burgess, JA and Zhai, G and Quinn, SJ and Jones, G (2008) Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian Older Adult Cohort (TASOAC) study. Annals of the Rheumatic Diseases, 67 (9). pp. 1256-1261. ISSN 0003-4967

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Abstract

Objective: To describe the associations between leptin,
body composition, sex and knee cartilage volume/defects
in older adults.
Methods: A cross-sectional sample of 190 randomly
selected subjects (mean 63 years, range 52–78, 48%
female) were studied. Knee cartilage volume and defects
were determined using T1-weighted fat saturation MRI.
Serum leptin levels were measured by radioimmunoassay.
Fat and lean mass were measured by dual energy x ray
absorptiometry (DXA). Body mass index (BMI) was
calculated.
Results: In multivariable analysis, serum levels of leptin
were negatively associated with total cartilage volume (b:
2541 mm3/log transformed unit, 95% CI 2861 to 2221)
but not with prevalent knee cartilage defects. BMI was
negatively associated with cartilage volume after adjustment
for total lean mass and positively with prevalent
knee cartilage defects. However, the association between
BMI and cartilage volume disappeared after adjustment
for leptin while the association between BMI and cartilage
defects remained unchanged. Lastly, sex differences in
total cartilage volume decreased substantially after
adjustment for leptin (R2 from 51% to 30%).
Conclusions: This cross-sectional study suggests cartilage
volume loss with obesity and female sex is related to
leptin and, thus, is hormonally mediated in older adults. By
contrast, obesity related knee focal cartilage defects may
be more related to non-hormonal factors.

Item Type: Article
Journal or Publication Title: Annals of the Rheumatic Diseases
Page Range: pp. 1256-1261
ISSN: 0003-4967
Identification Number - DOI: 10.1136/ard.2007.082651
Date Deposited: 16 Sep 2008 06:23
Last Modified: 18 Nov 2014 03:50
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