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Modification of ion chromatographic separations by ionic and nonionic surfactants


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Fritz, JS, Zhu, Y and Haddad, PR 2003 , 'Modification of ion chromatographic separations by ionic and nonionic surfactants' , Journal of Chromatography A, vol. 997, no. 1-2 , pp. 21-31 , doi: 10.1016/S0021-9673(03)00114-6.

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New findings are reported on simple ways to modify an ordinary HPLC column to obtain efficient ion chromatographic (IC) separations. Permanently coating a column with an ionic surfactant is known to produce an effective column for IC. We now show that incorporation of a nonionic surfactant in the coating, or coating in separate layers, results in a dramatic reduction of ion retention times and gives sharper peaks. Dynamic coating by incorporating a small amount of an alcohol, diol or zwitterion in the aqueous mobile phase permits good separations of alkanecarboxylic acids. A mobile phase containing a quaternary ammonium cation and a zwitterion anion provides excellent separations of common anions on a silica C18 column. An aqueous eluent containing a mixture of a zwitterion 4-(2-hydroxyethyl) acid and methanesulfonic acid can be used in conjunction with a standard cation exchange column. After passing through a membrane suppressor, the mobile phase has a slightly acidic pH, permitting divalent transition metal ions (as well as others) to be detected by conductivity.

Item Type: Article
Authors/Creators:Fritz, JS and Zhu, Y and Haddad, PR
Keywords: Surfactants; Inorganic anions; Inorganic cations; Organic acids; Coated columns; Dynamic coating
Journal or Publication Title: Journal of Chromatography A
ISSN: 0021-9673
DOI / ID Number: 10.1016/S0021-9673(03)00114-6
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