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Fast separation of pyrimidine derivatives by capillary electrochromatography on ion-exchange/reversed-phase mixed-mode stationary phases

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Klampfl, CW, Buchberger, W and Haddad, PR 2001 , 'Fast separation of pyrimidine derivatives by capillary electrochromatography on ion-exchange/reversed-phase mixed-mode stationary phases' , Journal of Chromatography A, vol. 911, no. 2 , pp. 277-283 , doi: 10.1016/S0021-9673(01)00515-5.

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Abstract

This work describes the use of mixed–mode stationary phases which exhibit both strong ion-exchange (either cation-exchange, SCX, or anion-exchange, SAX) and reversed-phase chromatographic characteristics in capillary electrochromatographic separations of pyrimidine derivatives. Different packing materials, namely C6, SCX/C6 and SAX/C6, were compared and the influence of the composition of the carrier electrolyte (concentration of acetonitrile and pH) on the retention behavior of the selected solutes was investigated. A separation of all eight pyrimidine derivatives could be obtained on a 6.5 cm column packed with the SAX/C6 stationary phase in less than 3 min, with good peak shapes and efficiencies in the range 39 000 to 81 000 plates per meter.

Item Type: Article
Authors/Creators:Klampfl, CW and Buchberger, W and Haddad, PR
Keywords: Pyrimidines; Electrochromatography; Stationary phases, electrochromatography; Mixed-mode chromatography
Journal or Publication Title: Journal of Chromatography A
ISSN: 0021-9673
DOI / ID Number: 10.1016/S0021-9673(01)00515-5
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