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Behavior of basic compounds in ion-exchange capillary electrochromatography with low-pH carrier electrolytes


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Klampfl, CW and Haddad, PR 2000 , 'Behavior of basic compounds in ion-exchange capillary electrochromatography with low-pH carrier electrolytes' , Journal of Chromatography A, vol. 884, no. 1-2 , pp. 277-285 , doi: 10.1016/S0021-9673(99)01314-X.

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This work describes the separation of basic aromatic compounds by capillary electrochromatography employing acidic carrier electrolytes and bare silica as well as strong cation-exchange stationary phases. A mixed-mode separation mechanism was involved, comprising chromatographic interactions (adsorption, ion-exchange) as well as electrophoretic migration. The influence of ion-exchange on the retention/migration of the solutes could be manipulated according to procedures commonly employed in ion chromatography. These include variations of the eluting strength and/or the concentration of the competing ion present in the background electrolyte. Using this approach, separation times could be shortened and changes in selectivity could be achieved for a number of analytes.

Item Type: Article
Authors/Creators:Klampfl, CW and Haddad, PR
Keywords: Aniline; Toluidines; Pyridine; Benzylamine; Aminopyridines; Electrochromatography; Background electrolyte composition; Mixed-mode chromatography
Journal or Publication Title: Journal of Chromatography A
ISSN: 0021-9673
DOI / ID Number: 10.1016/S0021-9673(99)01314-X
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