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A pilot study of the reproducibility and validity of measuring knee subchondral bone density in the tibia


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Dore, DA, Ding, C and Jones, G 2008 , 'A pilot study of the reproducibility and validity of measuring knee subchondral bone density in the tibia' , Osteoarthritis & Cartilage, vol. 16, no. 12 , pp. 1539-1544 , doi: 10.1016/j.joca.2008.04.012.

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Objective: To describe the reproducibility and validity of six different measurement techniques for knee subchondral bone mineral density
Methods: A consecutive sample of 50 male and female participants from a population-based longitudinal study had sBMD assessed using
dual energy X-ray absorptiometry scans. Anthropometric, knee pain, cartilage and bone measures by magnetic resonance imaging and radiographic
osteoarthritis (OA) were assessed. The six methods were defined as: (1) the midpoint of one intercondylar spine, across the tibial
surface and descending 10 mm; from the midpoint of the two intercondylar spines (2) the top of the spine descending 20 mm, (3) 10-20 mm
beneath the top of the spine; from the tibial surface descending, (4) 10 mm, (5) 15 mm, and (6) 20 mm.
Results: All six methods had excellent reproducibility (intra-class correlation coefficient 0.98-1.00). sBMD was higher in males (methods 2-4)
and higher in those with medial tibial osteophytes (methods 1, 3 and 4). Medial tibial cartilage defects and overall cartilage defects correlated
with sBMD (methods 3 and 4). Method 2, which includes the intercondylar spine, correlated with medial tibial bone size. Measuring sBMD
using methods 3 and 4 produced the greatest number of associations with joint features of OA.
Conclusions: These preliminary results need confirmation in larger longitudinal samples but suggest that sBMD can be accurately measured
and plays a role in knee OA. Methods 3 and 4 had the best concurrent validity; however, method 2 adds additional information on tibial bone
size, suggesting that two measures are necessary in clinical studies.

Item Type: Article
Authors/Creators:Dore, DA and Ding, C and Jones, G
Keywords: Osteoarthritis, Knee, Subchondral bone, Dual energy X-ray absorptiometry
Journal or Publication Title: Osteoarthritis & Cartilage
ISSN: 1063-4584
DOI / ID Number: 10.1016/j.joca.2008.04.012
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