PDF Burgess_J_Aller...pdf | Request a copy Full text restricted Available under University of Tasmania Standard License.

Abstract

Background: The association between eczema and asthma is
well documented, but the temporal sequence of this association
has not been closely examined.
Objectives: To examine the association between childhood
eczema and asthma incidence from preadolescence to middle
age, and between childhood eczema and asthma persisting to
middle age. A further aim was to examine any effect
modification by nonallergic childhood exposures on the
association between childhood eczema and both childhood
asthma and later life incident asthma.
Methods: Data were gathered from the 1968, 1974, and 2004
surveys of the Tasmanian Longitudinal Health Study.
Multivariable logistic regression examined the association
between childhood eczema and childhood asthma. Cox regression
examined the association between childhood eczema and asthma
incidence in preadolescence, adolescence, and adult life. Binomial
regression examined the association between childhood eczema
and childhood asthma persisting to age 44 years.
Results: Childhood eczema was significantly associated with
childhood asthma and with incident asthma in preadolescence
(hazard ratio [HR], 1.70; 95% CI, 1.05-2.75), adolescence (HR,
2.14; 95% CI, 1.33-3.46), and adult life (HR, 1.63; 95% CI, 1.28-
2.09). Although childhood eczema was significantly associated
with asthma persisting from childhood to middle age (relative
risk, 1.54; 95% CI, 1.17-2.04), this association was no longer
evident when adjusted for allergic rhinitis. Conclusion: Childhood eczema increased the likelihood of
childhood asthma, of new-onset asthma in later life and of
asthma persisting into middle age.

Item Type:	Article
Authors/Creators:	Burgess, JA and Dharmage, SC and Byrnes, GB and Matheson, MC and Gurrin, LC and Wharton, CL and Johns, DP and Abramson, MJ and Hopper, JL and Walters, EH
Keywords:	Childhood eczema, incident asthma, persisting asthma
Journal or Publication Title:	Journal of Allergy and Clinical Immunology
ISSN:	0091-6749
DOI / ID Number:	https://doi.org/10.1016/j.jaci.2008.05.018
Additional Information:	The definitive version is available at http://www.sciencedirect.com
Item Statistics:	View statistics for this item

Actions (login required)

Item Control Page