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Abstract

A comparison of platinum-based and non-platinum-based chemotherapy regimens for the treatment of small cell lung cancer
Small cell lung cancer (SCLC) is a very aggressive form of cancer due to early metastasis. As a result, chemotherapy forms the mainstay of treatment. This review compared platinum-based chemotherapy regimens and non-platinum-based chemotherapy regimens for the treatment of SCLC. The results show that there is no significant difference between platinum-based and non-platinum-based chemotherapy regimens in terms of survival and overall (complete and partial) tumour response. However, platinum-based regimens did have better complete tumour response rates. Platinum-based regimens also had higher levels of nausea and vomiting, anaemia and thrombocytopenia toxicity. Further research into the quality of life associated with these treatment regimens is needed.

Item Type:	Article
Authors/Creators:	Amarasena, IU and Walters, JAE and Wood-Baker, R and Fong, K
Journal or Publication Title:	Cochrane Database of Systematic Reviews 2008
ISSN:	1469-493X
DOI / ID Number:	10.1002/14651858.CD006849.pub2
Additional Information:	The definitive published version is available online at: http://interscience.wiley.com
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