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Memory loss caused by B-amyloid protein is rescued by a B3-adrenoceptor agonist


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Gibbs, ME, Maksel, D, Gibbs, Z, Hou, X, Summers, RJ and Small, DH 2008 , 'Memory loss caused by B-amyloid protein is rescued by a B3-adrenoceptor agonist' , Neurobiology of Aging, vol. 31, no. 4 , pp. 614-624 , doi: 10.1016/j.neurobiolaging.2008.05.018.

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Accumulation of the neurotoxic β-amyloid protein (Aβ) in the brain is a key step in the pathogenesis of Alzheimer's disease (AD). Although transgenic mouse models of AD have been developed, there is a clear need for a validated animal model of Aβ-induced amnesia which can be used for toxicity testing and drug development. Intracranial injections of Aβ1–42 impaired memory in a single trial discriminative avoidance learning task in chicks. Memory inhibition was closely associated with the state of aggregation of the Aβ peptide, and a scrambled-sequence of Aβ1–42 peptide failed to impair memory. Aβ had little effect on labile (short-term and intermediate) memory, but blocked consolidation of memory into long-term storage mimicking the type of anterograde amnesia that occurs in early AD. Since noradrenaline exerts a modulatory influence on labile memory in the chick, we examined the effects of two β-adrenoceptor (AR) agonists on Aβ-induced amnesia. A β3-AR agonist (CL316243), but not a β2-AR agonist, rescued Aβ-induced memory loss, suggesting the need for further studies on the role of β3-ARs in AD.

Item Type: Article
Authors/Creators:Gibbs, ME and Maksel, D and Gibbs, Z and Hou, X and Summers, RJ and Small, DH
Keywords: Chick; Amyloid; Abeta; Dementia; Memory; Alzheimer's disease; Neurotoxicity; Passive avoidance
Journal or Publication Title: Neurobiology of Aging
ISSN: 0197-4580
DOI / ID Number: 10.1016/j.neurobiolaging.2008.05.018
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