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UVR, Vitamin D and Three Autoimmune Diseases - Multiple Sclerosis, Type 1 Diabetes, Rheumatoid Arthritis


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Ponsonby, AL, Lucas, RM and van der Mei, IAF 2005 , 'UVR, Vitamin D and Three Autoimmune Diseases - Multiple Sclerosis, Type 1 Diabetes, Rheumatoid Arthritis' , Photochemistry and Photobiology, vol. 81, no. 6 , pp. 1267-1275 , doi: 10.1562/2005-02-15-IR-441.

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Here, we review the evidence indicating a possible beneficial role for UVR on three T helper type 1-mediated autoimmune diseases: multiple sclerosis, type 1 diabetes and rheumatoid arthritis in relation to recent developments in photoimmunology. Recent work suggests that UVR exposure may be one factor that can attenuate the autoimmune activity leading to these three diseases through several pathways involving UVB and UVA irradiation, UVR-derived vitamin D synthesis and other routes such as via a-melanocyte-stimulating hormone, calcitonin gene related peptide and melatonin. Ecological features, particularly a gradient of increasing prevalence of multiple sclerosis and type 1 diabetes with higher latitude, provide some support for a beneficial role of UVR. Analytical studies provide additional support, particularly as low vitamin D has been prospectively associated with disease onset for all three diseases, but are not definitive. Randomised controlled trial data are required. Further, we discuss how associated genetic studies may assist the accumulation of evidence with regard to the possible causal role of low UVR exposure and/or low vitamin D status in the development of these diseases.

Item Type: Article
Authors/Creators:Ponsonby, AL and Lucas, RM and van der Mei, IAF
Keywords: Ultraviolet radiation, vitamin D, multiple sclerosis, Type 1 Diabetes, Rheumatoid Arthritis, autoimmune disease, vitamin D receptor, immunosuppression.
Journal or Publication Title: Photochemistry and Photobiology
DOI / ID Number: 10.1562/2005-02-15-IR-441
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