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Abstract

Objective:

To generate hypotheses regarding the associations between knee cartilage defects and knee radiographic osteoarthritis (ROA), cartilage volume, bone size and type II collagen breakdown in adults.

Methods:

A cross-sectional convenience sample of 372 male and female subjects (mean age 45 years, range 26-61) was studied. Knee cartilage defect score (0-4) and prevalence (a defect score of >=2), cartilage volume, and bone surface area were determined using T1-weighted fat saturation MRI. Urinary levels of C-terminal crosslinking telopeptide of type II collagen (U-CTX-II) were measured by enzyme-linked immunosorbent assay. Height, weight and ROA were measured by standard protocols.

Results:

In multivariate analysis, the severity and prevalence of knee cartilage defects were significantly and independently associated with tibiofemoral osteophytes (regression coefficient (beta): +0.86 to +1.31/unit, odds ratio (OR): 2.97-3.68/unit, all P < 0.05 with the exception of OR in lateral tibiofemoral compartment) and tibial bone area (beta: +0.11 to +0.25/cm2; OR: 1.33-1.58/cm2, all P < 0.01). Knee cartilage defects were inconsistently associated with joint space narrowing after adjustment for osteophytes but consistently with knee cartilage volume (beta: -0.27 to -0.70/ml; OR: 0.16-0.56/ml, all P < 0.01 except for OR at lateral tibial cartilage site P = 0.06). Lastly, knee cartilage defect severity was significantly associated with U-CTX-II (Partial r = +0.18, P < 0.001 for total cartilage defect score).

Conclusion:

Osteophytes and increasing knee bone size may be causally related to knee cartilage defects. Furthermore, knee cartilage defects may result in increased cartilage breakdown leading to decreased cartilage volume and joint space narrowing suggesting an important role for knee cartilage defects in early knee OA.

Item Type:	Article
Authors/Creators:	Ding, C and Garnero, P and Cicuttini, F and Scott, F and Cooley, H and Jones, G
Keywords:	Knee; Cartilage defects; Osteoarthritis; Volume; Bone area; Type II collagen
Journal or Publication Title:	Osteoarthritis and Cartilage
ISSN:	1063-4584
DOI / ID Number:	10.1016/j.joca.2004.11.007
Additional Information:	Definitive version available online at: http://www.sciencedirect.com/
Item Statistics:	View statistics for this item

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