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Assessment of Thrombin generation: useful or hype?

Adams, MJ 2009 , 'Assessment of Thrombin generation: useful or hype?' , Seminars in Thrombosis and Hemostasis, vol. 35, no. 7 , pp. 104-110 , doi:

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Thrombin plays an important role in hemostasis through its multiple functions
across blood coagulation, platelet activation, and fibrinolysis. The measurement of
thrombin generation is therefore viewed as a potentially useful test that could be applied
to the screening, monitoring, and/or diagnosis of hemostatic abnormalities. Indeed,
advances in thrombin generation assays have created significant interest and debate as to
whether they may provide amore physiologically relevant testing system than do traditional
coagulation tests. A variety of thrombin generation assays, including commercially available
systems, have been investigated for their correlation with hypocoagulable and hypercoagulable
states. Although there is an extensive body of literature that has investigated the
application of thrombin generation assays, some limitations remain. These include poor
standardization of reagents and methods and a lack of large prospective studies that
demonstrate clear relationships between thrombin generation with bleeding and thrombosis
phenotypes, as well as with monitoring anticoagulation. Whether thrombin generation
assays become more ‘‘useful’’ than ‘‘hype’’ will require well-designed, large,
prospective multicenter trials using standardized methods.

Item Type: Article
Authors/Creators:Adams, MJ
Journal or Publication Title: Seminars in Thrombosis and Hemostasis
ISSN: 0094-6176
DOI / ID Number:
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Copyright # 2009 by
Thieme Medical Publishers, Inc.

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