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Abstract

Systemic lupus erythematosus (SLE) is a potentially fatal multiorgan inflammatory
disease that primarily affects females. Due to the heterogeneity of clinical manifestations
and lack of laboratory tests that are both specific and sensitive for the disease,
diagnosis of SLE can often be difficult. Although the precise etiology remains to be fully
elucidated, it is probable that various environmental, genetic, and hormonal factors
contribute to the development of the disease. Patients with SLE have an increased risk
for premature thrombosis and/or atherosclerosis, with up to half experiencing a thrombotic
event. Furthermore, antiphospholipid antibodies probably play a key role in the development
of thrombosis by affecting various hemostatic protein interactions with phospholipids
and cell surfaces as well as platelet function. Despite recent advances in knowledge related
to the factors that contribute to the pathophysiology of SLE, numerous challenges related
to earlier diagnosis as well as the prediction and prevention of thrombotic events remain to
be fully addressed.

Item Type:	Article
Authors/Creators:	Palatinus, AA and Adams, MJ
Keywords:	Systemic lupus erythematosus, lupus, thrombosis, antiphospholipid antibody
Journal or Publication Title:	Seminars in Thrombosis and Hemostasis
ISSN:	0094-6176
DOI / ID Number:	https://doi.org/10.1055/s-0029-1242716
Additional Information:	© 2009 by Thieme Medical Publishers, Inc. Definitive version available at www.thieme-connect.com
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