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Oral contraceptive use and bone mass in women aged 26–36 years


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Wei, S, Jones, G, Thomson, RJ, Dwyer, T and Venn, AJ 2010 , 'Oral contraceptive use and bone mass in women aged 26–36 years' , Osteoporosis International, vol. 22, no. 1 , pp. 351-355 , doi: 10.1007/s00198-010-1180-y.

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Introduction: The association between hormonal contraceptive
use and bone mineral density remains controversial.
Hypothesis Hormonal contraceptive use is positively associated with bone mass in young premenopausal women.
Methods: Cross-sectional analysis of data collected from
women aged 26–36 years (n=687) in the Childhood Determinants of Adult Health study—a longitudinal study
investigating childhood determinants of cardiovascular disease, diabetes, and other chronic diseases in adulthood.
Participants were not currently pregnant or breast-feeding.
Contraceptive use was obtained by self-administered questionnaire. Women were categorized as combined oral
contraceptive users (n=219), progestogen-only contraceptive
users (n=43), and non-users of hormonal contraceptives (n=
425). Bone mass was measured by quantitative ultrasound.
Results Compared with women who were not using any
hormonal contraceptives, women using combined oral contraceptives had significantly higher values of broadband ultrasound attenuation (BUA), speed of sound, and quantitative ultrasound index. These associations remained after adjustment for confounders. Progestogen-only contraceptive users had higher BUA than non-users, but the differences were not statistically significant in this small group.
Conclusion: Combined oral contraceptive use was associated
with higher bone mass measured by quantitative ultrasound in
this population-based sample of premenopausal women aged
26–36 while progestogen-only contraceptives appeared to
have no deleterious effect on bone mass.

Item Type: Article
Authors/Creators:Wei, S and Jones, G and Thomson, RJ and Dwyer, T and Venn, AJ
Keywords: Bone mass . Contraceptive . Oral contraceptive . Population . Progestogen . Quantitative ultrasound . Young women
Journal or Publication Title: Osteoporosis International
ISSN: 0937-941X
DOI / ID Number: 10.1007/s00198-010-1180-y
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