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Abstract

Thrombophilia refers to the increased tendency to form blood clots (thrombosis), which is a major cause of morbidity and
mortality. Thrombosis is associated with various chronic conditions such as cancer, diabetes, renal disorders, and cardiovascular disease.
The incidence and associated complications of thrombosis are likely to increase significantly in the next few decades because of aging
populations. Regular exercise has been proposed to decrease the risk of developing thrombosis, although there are inconsistent data
from studies investigating its effects, with reports of both increased and decreased thrombotic risk across a variety of subject cohorts.
Confounders such as age, gender, hormonal variations, physical activity, underlying disease and treatment, and body composition also
contribute to the difficulty in assessing and defining the precise effects of exercise in preventing thrombotic events. However, there
is evidence suggesting that physical activity is beneficial for reducing thrombotic risk in younger individuals and those with chronic
conditions. This article aims to summarize the known risk factors for thrombosis and briefly review the benefits of exercise in the
general population. Furthermore, this article highlights the additional factors in a cohort of individuals that would (at first) appear
unlikely to be at risk of thrombosis—elite athletes.

Item Type:	Article
Authors/Creators:	Adams, MJ and Fell, JW and Williams, AD
Keywords:	exercise; thrombosis; hemostasis; exercise prescription; thrombophilia
Journal or Publication Title:	Physician and Sportsmedicine
ISSN:	0091-3847
DOI / ID Number:	https://doi.org/10.3810/psm.2009.12.1750
Additional Information:	© 2008 The Physician and Sportsmedicine
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