Items where Author is "Pebay, A"

Bobba, S, Di Girolamo, N, Munsie, M, Chen, F, Pebay, A, Harkin, D, Hewitt, A

, O'Connor, M, McLenachan, S, Shadforth, AMA and Watson, SL 2018 , 'The current state of stem cell therapy for ocular disease' , Experimental Eye Research, vol. 177 , pp. 65-75 , doi: https://doi.org/10.1016/j.exer.2018.07.019.

Crombie, DE, Curl, CL, Raaijmakers, AJ, Sivakumaran, P, Kulkarni, T, Wong, RCB, Minami, I, Evans-Galea, MV, Lim, SY, Delbridge, L, Corben, LA, Dottori, M, Nakatsuji, N, Trounce, IA, Hewitt, AW

, Delatycki, MB, Pera, MF and Pebay, A 2017 , 'Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency' , Aging, vol. 9, no. 5 , pp. 1440-1452 , doi: https://doi.org/10.18632/aging.101247.

Crombie, DE, Daniszewski, M, Liang, HH, Kulkarni, T, Li, F

, Lidgerwood, GE, Conquest, A, Hernandez, D, Hung, SS, Gill, KP, De Smit, E, Kearns, LS, Clarke, L, Sluch, VM, Chamling, X, Zack, DJ, Wong, RCB, Hewitt, AW

and Pebay, A 2017 , 'Development of a modular automated system for maintenance and differentiation of adherent human pluripotent stem cells' , SLAS Discovery, vol. 22, no. 8 , pp. 1016-1025 , doi: https://doi.org/10.1177/2472555217696797.

Currant, H, Hysi, P, Fitzgerald, TW, Gharahkhani, P, Bonnemaijer, PWM, Senabouth, A, Hewitt, A

, Atan, D, Aung, T, Charng, J, Choquet, H, Craig, J, Khaw, PT, Klaver, CCW, Kubo, M, Ong, JS, Pasquale, LR, Reisman, CA, Daniszewski, M, Powell, JE, Pebay, A, Simcoe, MJ, Thiadens, AAHJ, van Duijn, CM, Yazar, S, Jorgenson, E, MacGregor, S, Hammond, CJ, Mackey, DA, Wiggs, JL, Foster, PJ, Patel, PJ, Birney, E and Khawaja, AP 2021 , 'Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images' , PLoS Genetics, vol. 17, no. 5 , pp. 1-27 , doi: https://doi.org/10.1371/journal.pgen.1009497.

Daniszewski, M, Crombie, DE, Henderson, R, Liang, HH, Wong, RCB, Hewitt, AW

and Pebay, A 2017 , 'Automated cell culture systems and their applications to human pluripotent stem cell studies' , SLAS Technology , pp. 1-11 , doi: https://doi.org/10.1177/2472630317712220.

Daniszewski, M, Nguyen, Q, Chy, HS, Singh, V

, Crombie, DE, Kulkarni, T, Liang, HH, Sivakumaran, P, Lidgerwood, GE, Hernandez, D, Conquest, A, Rooney, LA, Chevalier, S, Andersen, SB, Senabouth, A, Vickers, JC

, Mackey, DA, Craig, JE, Laslett, AL, Hewitt, AW

, Powell, JE and Pebay, A 2018 , 'Single-cell profiling identifies key pathways expressed by iPSCs cultured in different commercial media' , iScience, vol. 7 , pp. 30-39 , doi: https://doi.org/10.1016/j.isci.2018.08.016.

Daniszewski, M, Senabouth, A, Nguyen, QH, Crombie, DE, Lukowski, SW, Kulkarni, T, Sluch, VM, Jabbari, JS, Chamling, X, Zack, DJ, Pebay, A, Powell, JE and Hewitt, AW

2018 , 'Single cell RNA sequencing of stem cell-derived retinal ganglion cells' , Scientific Data, vol. 5 , pp. 1-9 , doi: https://doi.org/10.1038/sdata.2018.13.

De Smit, E, Lukowski, SW, Anderson, L, Senabouth, A, Dauyey, K, Song, S, Wyse, B, Wheeler, L, Chen, CY, Cao, K, Wong Ten Yuen, A, Shuey, N, Clarke, L, Lopez Sanchez, I, Hung, SSC, Pebay, A, Mackey, DA, Brown, MA, Hewitt, AW

and Powell, JE 2018 , 'Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis' , BMC Medical Genomics, vol. 11, no. 1 , pp. 1-16 , doi: https://doi.org/10.1186/s12920-018-0376-4.

Galloway, CA, Dalvi, S, Hung, SSC, MacDonald, LA, Latchney, LR, Wong, RCB, Guymer, RH, Mackey, DA, Williams, DS, Chung, MM, Gamm, DM, Pebay, A, Hewitt, AW

and Singh, R 2017 , 'Drusen in patient-derived hiPSC-RPE models of macular dystrophies' , Proceedings of the National Academy of Sciences of The United States of America, vol. 114, no. 39 , E8214-E8223 , doi: https://doi.org/10.1073/pnas.1710430114.

Hernandez, D, Rooney, LA, Daniszewski, M, Gulluyan, L, Liang, HH, Cook, AL

, Hewitt, AL

and Pebay, A 2021 , 'Culture variabilities of human iPSC-derived cerebral organoids are a major Issue for the modelling of phenotypes observed in Alzheimer's Disease' , Stem Cell Reviews and Reports , doi: https://doi.org/10.1007/s12015-021-10147-5.

Hoque, A, Sivakumaran, P, Bond, ST, Ling, NXY, Kong, AM, Scott, JW, Bandara, N, Hernandez, D, Liu, G-S

, Wong, RCB, Ryan, MT, Hausenloy, DJ, Kemp, BE, Oakhill, JS, Drew, BG, Pebay, A and Lim, SY 2018 , 'Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells' , Cell Death Discovery, vol. 4 , pp. 1-13 , doi: https://doi.org/10.1038/s41420-018-0042-9.

Karch, CM, Hernandez, D, Wang, J-C, Marsh, J, Hewitt, AW

, Hsu, S, Norton, J, Levitch, D, Donahue, T, Sigurdson, W, Ghetti, B, Farlow, M, Chhatwal, J, Berman, S, Cruchaga, C, Morris, JC, Bateman, RJ, Pebay, A and Goate, AM 2018 , 'Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network' , Alzheimer's Research and Therapy, vol. 10, no. 1 , pp. 1-11 , doi: https://doi.org/10.1186/s13195-018-0400-0.

Konttinen, H, Cabral-da-Silva, MeC, Ohtonen, S, Wojciechowski, S, Shakirzyanova, A, Caligola, S, Giugno, R, Ishchenko, Y, Hernandez, D, Fazaludeen, MF, Eamen, S, Budia, MG, Fagerlund, I, Scoyni, F, Korhonen, P, Huber, N, Haapasalo, A, Hewitt, AW

, Vickers, J

, Smith, GC, Oksanen, M, Graff, C, Kanninen, KM, Lehtonen, S, Propson, N, Schwartz, MP, Pebay, A, Koistinaho, J, Ooi, L and Malm, T 2019 , 'PSEN1ΔE9, APPswe, and APOE4 confer disparate phenotypes in human iPSC-derived microglia' , Stem Cell Reports, vol. 13, no. 4 , pp. 669-683 , doi: https://doi.org/10.1016/j.stemcr.2019.08.004.

Li, F

, Hung, SSC, Mohd Khalid, MKN, Wang, J-H, Chrysostomou, V, Wong, VHY, Singh, V

, Wing, K, Tu, L, Bender, JA

, Pebay, A, King, AE

, Cook, AL

, Wong, RCB, Bui, BV, Hewitt, AW

and Liu, G-S

2019 , 'Utility of self-destructing CRISPR/Cas constructs for targeted gene editing in the retina' , Human Gene Therapy, vol. 30, no. 11 , pp. 1349-1360 , doi: https://doi.org/10.1089/hum.2019.021.

Li, F

, Wing, K, Wang, J-H, Luu, CD, Bender, JA

, Chen, J, Wang, Q

, Lu, Q

, Nguyen Tran, MT, Young, KM

, Wong, RCB, Pebay, A, Cook, AL

, Hung, SSC, Liu, G-S

and Hewitt, AW

2020 , 'Comparison of CRISPR/Cas endonucleases for in vivo retinal gene editing' , Frontiers in Cellular Neuroscience, vol. 14 , pp. 1-9 , doi: https://doi.org/10.3389/fncel.2020.570917.

Lidgerwood, GE, Hewitt, AW

and Pebay, A 2019 , 'Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish' , Current Opinion in Pharmacology, vol. 48 , pp. 114-119 , doi: https://doi.org/10.1016/j.coph.2019.09.003.

Lidgerwood, GE, Morris, AJ, Conquest, A, Daniszewski, M, Rooney, LA, Lim, SY, Hernandez, D, Liang, HH, Allen, P, Connell, PP, Guymer, RH, Hewitt, AW

and Pebay, A 2018 , 'Role of lysophosphatidic acid in the retinal pigment epithelium and photoreceptors' , Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1863, no. 7 , pp. 750-761 , doi: https://doi.org/10.1016/j.bbalip.2018.04.007.

McCaughey, T, Budden, DM, Sanfilippo, PG, Gooden, GEC, Fan, L, Fenwick, E, Rees, G, Macgregor, C, Si, L

, Chen, C, Liang, HH, Pebay, A, Baldwin, T and Hewitt, AW

2019 , 'A need for better understanding is the major determinant for public perceptions of human gene editing' , Human Gene Therapy, vol. 30, no. 1 , pp. 36-43 , doi: https://doi.org/10.1089/hum.2018.033.

Munoz, SS, Engel, M, Balez, R, Do-Ha, D, Cabral-da-Silva, MC, Hernandez, D, Berg, T, Fifita, JA, Grima, N, Yang, S, Blair, IP, Nicholson, G, Cook, AL

, Hewitt, AW

, Pebay, A and Ooi, L 2020 , 'A simple differentiation protocol for generation of induced pluripotent stem cell-derived basal forebrain-like cholinergic neurons for Alzheimer's disease and frontotemporal dementia disease modeling' , Cells, vol. 9, no. 9 , pp. 1-17 , doi: https://doi.org/10.3390/cells9092018.

Neavin, D, Nguyen, Q, Daniszewsk, MS, Liang, HH, Chiu, HS, Wee, YK, Lukowski, SW, Crombie, DE, Lidgerwood, GE, Hernandez, D, Vickers, JC

, Cook, AL

, Palpant, NJ, Pebay, A, Hewitt, AW

and Powell, JE 2021 , 'Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells' , Genome Biology, vol. 22 , pp. 1-19 , doi: https://doi.org/10.1186/s13059-021-02293-3.

Nguyen Tran, MT, Mohd Khalid, MKN, Pebay, A, Cook, AL

, Liang, HH, Wong, RCB, Craig, JE, Liu, G-S

, Hung, SS and Hewitt, AW

2019 , 'Screening of CRISPR/Cas base editors to target the AMD high-risk Y402H complement factor H variant' , Molecular Vision, vol. 25 , pp. 174-182 .

Nguyen Tran, MT, Mohd Khalid, MKN, Wang, Q

, Walker, JKR, Lidgerwood, GE, Dilworth, KL, Lisowski, L, Pebay, A and Hewitt, AW

2020 , 'Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing' , Nature Communications, vol. 11, no. 1 , pp. 1-10 , doi: https://doi.org/10.1038/s41467-020-18715-y.

Ooi, L, Dottori, M, Cook, AL

, Engel, M, Gautam, V, Grubman, A, Hernandez, D, King, AE

, Maksour, S, Targa Dias Anastacio, H, Balez, R, Pebay, A, Pouton, C, Valenzuela, M, White, A and Williamson, R 2020 , 'If human brain organoids are the answer to understanding dementia, what are the questions?' , The Neuroscientist , pp. 1-17 , doi: https://doi.org/10.1177/1073858420912404.

Stellon, D, Nguyen Tran, MT, Talbot, J, Chear, S, Mohd Khalid, MKN, Pebay, A, Vickers, JC

, King, AE

, Hewitt, AW

and Cook, AL

2021 , 'CRISPR/Cas-Mediated Knock-in of genetically encoded fluorescent biosensors into the AAVS1 locus of human-induced pluripotent stem cells' , Methods in Molecular Biology , doi: https://doi.org/10.1007/7651_2021_422.

Talbot, J, Chear, S, Phipps, A

, Pebay, A, Hewitt, AW

, Vickers, JC

, King, AE

and Cook, AL

2021 , 'Image-based quantitation of kainic acid-induced excitotoxicity as a model of neurodegeneration in Human iPSC-Derived Neurons' , Methods in Molecular Biology , doi: https://doi.org/10.1007/7651_2021_421.

Wang, Q, Chear, S, Wing, K, Stellon, D, Tran, MTN, Talbot, J, Pebay, A, Hewitt, AW

and Cook, AL

2021 , 'Use of CRISPR/Cas ribonucleoproteins for high throughput gene editing of induced pluripotent stem cells' , Methods , pp. 1-12 , doi: https://doi.org/10.1016/j.ymeth.2021.02.009.

Wong, RCB, Hung, SS, Jackson, S, Singh, V

, Khan, Shahnaz, Liang, HH, Kearns, LS, Nguyena, T, Conquest, A, Daniszewski, M, Hewitt, AW

and Pebay, A 2017 , 'Generation of a human induced pluripotent stem cell line CERAi001-A-6 using episomal vectors' , Stem Cell Research, vol. 22 , pp. 13-15 , doi: https://doi.org/10.1016/j.scr.2017.05.007.

Wong, RCB, Lim, SY, Hung, SSC, Jackson, S, Khan, Shahnaz, Van Bergen, NJ, De Smit, E, Liang, HH, Kearns, LS, Clarke, L, Mackey, DA, Hewitt, AW

, Trounce, IA and Pebay, A 2017 , 'Mitochondrial replacement in an iPSC model of Leber's hereditary optic neuropathy' , Aging, vol. 9, no. 4 , pp. 1341-1350 , doi: https://doi.org/10.18632/aging.101231.

Xu, J, Falconer, C, Nguyen, Q, Crawford, J, McKinnon, BD, Mortlock, S, Senabouth, A, Andersen, S, Chiu, HS, Jiang, L, Palpant, NJ, Yang, J, Mueller, MD, Hewitt, AW

, Pebay, A, Montgomery, GW, Powell, JE and Coin, LJM 2019 , 'Genotype-free demultiplexing of pooled single-cell RNA-seq' , Genome Biology, vol. 20, no. 1 , pp. 1-12 , doi: https://doi.org/10.1186/s13059-019-1852-7.

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